| 1. Jornada | 26.10.2021 | Zamalek | - | ENPPI | 2:0 |  |
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| 2. Jornada | 31.10.2021 | Tala'ea El Gaish SC | - | Zamalek | 0:2 | ||||
| 3. Jornada | 05.11.2021 | Zamalek | - | Al Ahly SC | 3:5 | ||||
| 6. Jornada | 25.11.2021 | Ceramica Cleopatra | - | Zamalek | 0:1 | ||||
| 7. Jornada | 21.12.2021 | Al Mokawloon | - | Zamalek | 1:2 | ||||
| 8. Jornada | 25.12.2021 | Zamalek | - | Ghazl Al Mehalla | 4:0 | ||||
| 9. Jornada | 15.02.2022 | Smouha Sporting Club | - | Zamalek | 2:0 | |
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| 10. Jornada | 02.03.2022 | Zamalek | - | Future FC | 3:2 | ||||
| 12. Jornada | 07.03.2022 | Zamalek | - | El Gouna | 2:1 | ||||
| 11. Jornada | 06.04.2022 | Pyramids FC | - | Zamalek | 2:3 | ||||
| 13. Jornada | 09.04.2022 | Misr lel-Maqasah SC | - | Zamalek | 0:1 | ||||
| 14. Jornada | 12.04.2022 | Zamalek | - | Pharco FC | 0:0 | |
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| 15. Jornada | 19.04.2022 | Ittihad El Iskandary | - | Zamalek | 0:2 | |
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| 17. Jornada | 01.05.2022 | El Sharkia Lel Dokhan | - | Zamalek | 1:2 | |
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| 18. Jornada | 10.05.2022 | Zamalek | - | ENPPI | 0:2 | |
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| 21. Jornada | 28.05.2022 | Zamalek | - | Ismaily | 2:1 | |
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| 30. Jornada | 09.08.2022 | Zamalek | - | Misr lel-Maqasah SC | 5:0 | ||||
| 32. Jornada | 23.08.2022 | Zamalek | - | Ittihad El Iskandary | 1:1 | ||||
| 33. Jornada | 26.08.2022 | Al Masry Club | - | Zamalek | 0:0 |
Egipto