| 4. Jornada | 15.08.2022 | Real España | - | Victoria | 2:1 |  |
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| 5. Jornada | 22.08.2022 | Olimpia | - | Real España | 1:1 | ||||
| 6. Jornada | 29.08.2022 | Real España | - | Marathón | 2:0 | ||||
| 7. Jornada | 01.09.2022 | Vida | - | Real España | 1:0 | ||||
| 9. Jornada | 12.09.2022 | Real España | - | Honduras Progreso | 2:0 |  |
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| 10. Jornada | 19.09.2022 | Lobos UPNFM | - | Real España | 2:2 | ||||
| 11. Jornada | 02.10.2022 | Motagua | - | Real España | 1:2 | ||||
| 12. Jornada | 08.10.2022 | Real España | - | Real Sociedad | 1:3 | ||||
| 13. Jornada | 16.10.2022 | Victoria | - | Real España | 1:4 |
Honduras