| 1. Jornada | 24.07.2021 | FK Yessentuki | - | FK Biolog Novokubansk | 0:5 |  |
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| 2. Jornada | 01.08.2021 | FK Legion Dynamo Makhachkala | - | FK Yessentuki | 3:1 |  |
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| 4. Jornada | 15.08.2021 | Spartak Nalchik | - | FK Yessentuki | 2:1 | |
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| 5. Jornada | 20.08.2021 | FK Yessentuki | - | FK Chayka | 1:9 | ||||
| 6. Jornada | 30.08.2021 | Anzhi Makhachkala | - | FK Yessentuki | 5:0 | ||||
| 7. Jornada | 04.09.2021 | FK Yessentuki | - | FK Druzhba | 2:1 | ||||
| 8. Jornada | 08.09.2021 | Alania-2 Vladikavkaz | - | FK Yessentuki | 1:1 | ||||
| 9. Jornada | 13.09.2021 | FK Yessentuki | - | Kuban-Holding Pavlovskaya | 1:2 | ||||
| 10. Jornada | 18.09.2021 | Forte Taganrog | - | FK Yessentuki | 6:0 | ||||
| 11. Jornada | 27.09.2021 | FK Yessentuki | - | FK Dinamo Makhachkala | 0:2 | ||||
| 12. Jornada | 05.10.2021 | Rotor-2 Volgograd | - | FK Yessentuki | 6:0 | |
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| 13. Jornada | 11.10.2021 | FK Yessentuki | - | FK Tuapse | 1:4 | ||||
| 16. Jornada | 31.10.2021 | Chernomorets Novorossisk | - | FK Yessentuki | 5:0 | ||||
| 18. Jornada | 12.11.2021 | FK Yessentuki | - | FK Legion Dynamo Makhachkala | 0:6 |
Rusia