| 4. Jornada | 07.08.2021 | FK Orenburg 2 | - | Irtysh Omsk | 1:1 | ||||
| 5. Jornada | 18.08.2021 | Irtysh Omsk | - | Zvezda Perm | 1:0 |  |
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| 6. Jornada | 21.08.2021 | Irtysh Omsk | - | FK Tyumen | 2:4 | ||||
| 7. Jornada | 02.09.2021 | FK Ural 2 | - | Irtysh Omsk | 1:1 | |
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| 8. Jornada | 05.09.2021 | FK Chelyabinsk | - | Irtysh Omsk | 4:1 | |
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| 9. Jornada | 14.09.2021 | Irtysh Omsk | - | Spartak Tuymazy | 3:1 | ||||
| 10. Jornada | 17.09.2021 | Irtysh Omsk | - | Torpedo Miass | 1:0 | ||||
| 11. Jornada | 27.09.2021 | Lada Tolyatti | - | Irtysh Omsk | 2:2 | ||||
| 12. Jornada | 30.09.2021 | Volga Ulyanovsk | - | Irtysh Omsk | 6:1 | ||||
| 13. Jornada | 13.10.2021 | Irtysh Omsk | - | FK Novosibirsk | 3:1 | ||||
| 15. Jornada | 17.10.2021 | Dinamo Barnaul | - | Irtysh Omsk | 1:1 | ||||
| 16. Jornada | 20.10.2021 | FK Novosibirsk | - | Irtysh Omsk | 2:0 | |
Rusia