| Dieciseisavos de final | 18.02.2016 | Shakhtar Donetsk | - | Schalke | 0:0 | ||||
| Dieciseisavos de final | 25.02.2016 | Schalke | - | Shakhtar Donetsk | 0:3 | ||||
| Octavos de final | 10.03.2016 | Shakhtar Donetsk | - | RSC Anderlecht | 3:1 | ||||
| Octavos de final | 17.03.2016 | RSC Anderlecht | - | Shakhtar Donetsk | 0:1 | ||||
| Cuartos de final | 07.04.2016 | Sporting Braga | - | Shakhtar Donetsk | 1:2 | ||||
| Cuartos de final | 14.04.2016 | Shakhtar Donetsk | - | Sporting Braga | 4:0 | ||||
| Semifinales | 28.04.2016 | Shakhtar Donetsk | - | Sevilla | 2:2 |  |
|||
| Semifinales | 05.05.2016 | Sevilla | - | Shakhtar Donetsk | 3:1 |
Ucrania