| 1. Jornada | 19.09.2021 | UE Santa Coloma | - | FC Santa Coloma | 2:1 |  |
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| 2. Jornada | 26.09.2021 | FC Santa Coloma | - | UE Engordany | 1:1 | |
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| 3. Jornada | 03.10.2021 | CE Carroi | - | FC Santa Coloma | 2:5 | ||||
| 4. Jornada | 17.10.2021 | FC Santa Coloma | - | FC Ordino | 3:2 | ||||
| 5. Jornada | 24.10.2021 | FC Santa Coloma | - | UE Sant Julià | 1:3 | ||||
| 6. Jornada | 31.10.2021 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:1 | ||||
| 7. Jornada | 07.11.2021 | FC Santa Coloma | - | Atlétic Escaldes | 1:3 |  |
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| 10. Jornada | 19.12.2021 | FC Santa Coloma | - | CE Carroi | 3:0 | ||||
| 12. Jornada | 19.01.2022 | UE Sant Julià | - | FC Santa Coloma | 0:0 | ||||
| 11. Jornada | 02.02.2022 | FC Ordino | - | FC Santa Coloma | 0:0 | ||||
| 19. Jornada | 13.03.2022 | FC Santa Coloma | - | UE Sant Julià | 2:0 | ||||
| 20. Jornada | 20.03.2022 | Inter Club d'Escaldes | - | FC Santa Coloma | 1:2 | ||||
| 21. Jornada | 03.04.2022 | FC Santa Coloma | - | Atlétic Escaldes | 1:1 |
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