| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 10.09.2022 | Guaireña FC | - | Libertad | 4:0 |  |
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| 18. Jornada | 21.10.2022 | Guaireña FC | - | Sol de América | 0:0 | ||||
| 19. Jornada | 27.10.2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Libertad | - | Guaireña FC | 4:2 | ||||
| 22. Jornada | 12.11.2022 | Guaireña FC | - | Cerro Porteño | 1:3 |
Paraguay