| 1. Jornada | 05.02.2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
| 2. Jornada | 11.02.2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
| 3. Jornada | 20.02.2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
| 5. Jornada | 07.03.2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
| 6. Jornada | 11.03.2022 | Sportivo Ameliano | - | Tacuary | 0:2 |  |
 |
||
| 7. Jornada | 21.03.2022 | Tacuary | - | Club Nacional | 2:1 | ||||
| 8. Jornada | 04.04.2022 | Guaraní | - | Tacuary | 1:2 | |
|||
| 9. Jornada | 11.04.2022 | Tacuary | - | Guaireña FC | 0:1 | |
|||
| 10. Jornada | 19.04.2022 | Sol de América | - | Tacuary | 1:0 | ||||
| 11. Jornada | 22.04.2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
| 12. Jornada | 26.04.2022 | Tacuary | - | Resistencia SC | 3:1 | |
|||
| 13. Jornada | 30.04.2022 | 12 de Octubre de Itauguá | - | Tacuary | 2:0 | ||||
| 14. Jornada | 07.05.2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
| 16. Jornada | 16.05.2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
| 17. Jornada | 20.05.2022 | Tacuary | - | Sportivo Ameliano | 1:0 | ||||
| 18. Jornada | 13.06.2022 | Club Nacional | - | Tacuary | 3:0 | ||||
| 21. Jornada | 28.06.2022 | Tacuary | - | Sol de América | 2:2 | ||||
| 22. Jornada | 02.07.2022 | Cerro Porteño | - | Tacuary | 1:0 | |
Paraguay