| 1. Jornada | 25.07.2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 3. Jornada | 08.08.2021 | Pumas UNAM | - | Atlético San Luis | 1:3 | ||||
| 4. Jornada | 15.08.2021 | Pumas UNAM | - | Gallos Blancos | 0:0 | ||||
| 5. Jornada | 18.08.2021 | Club Necaxa | - | Pumas UNAM | 3:0 | ||||
| 6. Jornada | 22.08.2021 | Pumas UNAM | - | Puebla FC | 2:0 | ||||
| 7. Jornada | 29.08.2021 | Deportivo Toluca | - | Pumas UNAM | 2:1 | ||||
| 8. Jornada | 13.09.2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
| 9. Jornada | 19.09.2021 | Mazatlán FC | - | Pumas UNAM | 2:2 | ||||
| 14. Jornada | 21.10.2021 | Club León | - | Pumas UNAM | 1:2 |  |
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| 15. Jornada | 24.10.2021 | Pumas UNAM | - | Club Tijuana | 3:1 |
México