| 1. Jornada | 25.08.2018 | Tuxtla FC | - | Cocodrilos de Tabasco | 2:1 |  |
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| 2. Jornada | 01.09.2018 | Albinegros Orizaba | - | Tuxtla FC | 0:1 |  |
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| 3. Jornada | 08.09.2018 | Tuxtla FC | - | Real Zamora | 3:0 | ||||
| 4. Jornada | 15.09.2018 | Deportivo Toluca II | - | Tuxtla FC | 3:2 | |
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| 5. Jornada | 22.09.2018 | Tuxtla FC | - | Sporting Canamy | 5:0 | |
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| 6. Jornada | 30.09.2018 | Pioneros de Cancún | - | Tuxtla FC | 0:0 | |
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| 7. Jornada | 06.10.2018 | Tuxtla FC | - | Tuzos de la UAZ | 4:1 | |
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| 8. Jornada | 13.10.2018 | Coyotes de Tlaxcala | - | Tuxtla FC | 3:0 | ||||
| 9. Jornada | 20.10.2018 | Tuxtla FC | - | Club Irapuato | 0:2 | ||||
| 10. Jornada | 28.10.2018 | Reboceros de La Piedad | - | Tuxtla FC | 0:3 | |
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| 11. Jornada | 03.11.2018 | Tuxtla FC | - | Inter Playa | 1:1 | |
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| 12. Jornada | 11.11.2018 | Yalmakan FC | - | Tuxtla FC | 2:3 | ||||
| 13. Jornada | 17.11.2018 | Tuxtla FC | - | CF América II | 1:1 | |
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| 14. Jornada | 24.11.2018 | Tuxtla FC | - | Cruz Azul Hidalgo | 2:0 |
México