| 4. Jornada | 21.08.2021 | SC Paderborn 07 | - | FC St. Pauli | 3:1 | ||||
| 5. Jornada | 29.08.2021 | Dynamo Dresden | - | SC Paderborn 07 | 0:3 | ||||
| 6. Jornada | 12.09.2021 | SC Paderborn 07 | - | Schalke | 0:1 | ||||
| 7. Jornada | 19.09.2021 | Erzgebirge Aue | - | SC Paderborn 07 | 1:4 |  |
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| 8. Jornada | 25.09.2021 | SC Paderborn 07 | - | Holstein Kiel | 1:2 | ||||
| 9. Jornada | 02.10.2021 | Fortuna Düsseldorf | - | SC Paderborn 07 | 2:3 | ||||
| 10. Jornada | 15.10.2021 | SC Paderborn 07 | - | Jahn Regensburg | 1:1 | ||||
| 12. Jornada | 31.10.2021 | Karlsruher SC | - | SC Paderborn 07 | 2:4 | ||||
| 18. Jornada | 18.12.2021 | SC Paderborn 07 | - | 1. FC Heidenheim 1846 | 1:2 | ||||
| 19. Jornada | 15.01.2022 | 1. FC Nürnberg | - | SC Paderborn 07 | 1:2 |  |
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| 21. Jornada | 05.02.2022 | FC St. Pauli | - | SC Paderborn 07 | 2:2 | |
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| 22. Jornada | 12.02.2022 | SC Paderborn 07 | - | Dynamo Dresden | 0:0 | ||||
| 23. Jornada | 18.02.2022 | Schalke | - | SC Paderborn 07 | 2:0 | ||||
| 24. Jornada | 25.02.2022 | SC Paderborn 07 | - | Erzgebirge Aue | 3:3 | ||||
| 26. Jornada | 12.03.2022 | SC Paderborn 07 | - | Fortuna Düsseldorf | 1:1 | ||||
| 27. Jornada | 20.03.2022 | Jahn Regensburg | - | SC Paderborn 07 | 1:0 | |
Alemania