| 1. Jornada | 06.02.2022 | Real Santa Cruz | - | Universitario de Sucre | 0:1 | ||||
| 2. Jornada | 13.02.2022 | Real Santa Cruz | - | CD Guabirá | 2:2 |  |
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| 3. Jornada | 18.02.2022 | Nacional Potosí | - | Real Santa Cruz | 1:0 | |
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| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 13. Jornada | 08.05.2022 | Always Ready | - | Real Santa Cruz | 5:0 |
Bolivia