| 18. Jornada | 11.09.2021 | Royal Pari | - | Club San José | 6:1 | ||||
| 19. Jornada | 17.09.2021 | Club San José | - | Real Potosí | 0:0 | ||||
| 20. Jornada | 21.09.2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Jornada | 20.10.2021 | Bolívar | - | Club San José | 4:1 | ||||
| 23. Jornada | 22.10.2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 24. Jornada | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 | ||||
| 26. Jornada | 22.11.2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 27. Jornada | 26.11.2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Jornada | 30.11.2021 | Club San José | - | Oriente Petrolero | 0:2 | ||||
| 29. Jornada | 05.12.2021 | The Strongest | - | Club San José | 2:0 |
Bolivia