| 1. Jornada | 07.08.2021 | Freiburger FC | - | Neckarsulmer Sport-Union | 2:3 | ||||
| 2. Jornada | 14.08.2021 | Neckarsulmer Sport-Union | - | TSV Ilshofen | 4:1 |  |
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| 3. Jornada | 21.08.2021 | 1. FC Bruchsal | - | Neckarsulmer Sport-Union | 3:1 | ||||
| 6. Jornada | 04.09.2021 | Neckarsulmer Sport-Union | - | FV Lörrach-Brombach | 2:0 | |
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| 7. Jornada | 10.09.2021 | FC Nöttingen | - | Neckarsulmer Sport-Union | 2:1 | ||||
| 8. Jornada | 15.09.2021 | Neckarsulmer Sport-Union | - | SV Oberachern | 1:0 | ||||
| 9. Jornada | 18.09.2021 | Stuttgarter Kickers | - | Neckarsulmer Sport-Union | 1:0 | ||||
| 10. Jornada | 25.09.2021 | Neckarsulmer Sport-Union | - | FC-Astoria Walldorf II | 1:3 |
Alemania