| 4. Jornada | 22.08.2021 | FK Skopje | - | FK Pelister | 1:0 |  |
|||
| 5. Jornada | 28.08.2021 | KF Shkupi | - | FK Skopje | 4:1 | ||||
| 6. Jornada | 12.09.2021 | FC Struga | - | FK Skopje | 1:0 | ||||
| 7. Jornada | 19.09.2021 | FK Skopje | - | KF Shkëndija 79 | 0:2 | ||||
| 8. Jornada | 26.09.2021 | FK Borec | - | FK Skopje | 0:2 | |
|||
| 9. Jornada | 02.10.2021 | FK Skopje | - | FK AP Brera Strumica | 0:0 | ||||
| 10. Jornada | 15.10.2021 | FK Rabotnički | - | FK Skopje | 0:1 | ||||
| 11. Jornada | 24.10.2021 | FK Skopje | - | GFK Tikvesh | 2:1 | |
|||
| 12. Jornada | 30.10.2021 | FK Skopje | - | FK Renova | 0:0 | ||||
| 13. Jornada | 06.11.2021 | FK Bregalnica Štip | - | FK Skopje | 2:1 | ||||
| 14. Jornada | 20.11.2021 | FK Skopje | - | Makedonija GP | 1:2 | |
|||
| 15. Jornada | 28.11.2021 | FK Pelister | - | FK Skopje | 0:0 | |
|||
| 17. Jornada | 08.12.2021 | FK Skopje | - | FC Struga | 1:0 | ||||
| 18. Jornada | 12.12.2021 | KF Shkëndija 79 | - | FK Skopje | 1:0 |
Macedonia del Norte