| 11. Jornada | 19.03.2022 | UANL Tigres [Sub 16] | - | Mazatlán FC [Sub 16] | 0:0 | ||||
| 15. Jornada | 16.04.2022 | Atlas Guadalajara [Sub 16] | - | Mazatlán FC [Sub 16] | 5:0 | ||||
| 16. Jornada | 23.04.2022 | Mazatlán FC [Sub 16] | - | Atlético San Luis [Sub 16] | 2:1 |  |
 |
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| 17. Jornada | 30.04.2022 | Club Tijuana [Sub 16] | - | Mazatlán FC [Sub 16] | 1:2 |
México