| 1. Jornada | 16.01.2022 | Santa Lucía | - | CSD Municipal | 0:2 |  |
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| 2. Jornada | 22.01.2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 3. Jornada | 30.01.2022 | Sololá FC | - | CSD Municipal | 0:3 | ||||
| 4. Jornada | 02.02.2022 | CSD Municipal | - | Comunicaciones | 2:0 | ||||
| 5. Jornada | 06.02.2022 | Deportivo Malacateco | - | CSD Municipal | 2:1 | ||||
| 6. Jornada | 09.02.2022 | CSD Municipal | - | Xelaju MC | 2:2 | |
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| 7. Jornada | 13.02.2022 | Nueva Concepción | - | CSD Municipal | 1:0 | ||||
| 18. Jornada | 20.04.2022 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 20. Jornada | 30.04.2022 | CSD Municipal | - | Iztapa | 3:1 | ||||
| 21. Jornada | 04.05.2022 | CSD Municipal | - | Antigua GFC | 0:1 |
Guatemala