| 1. Jornada | 23.07.2022 | CSD Municipal | - | Cobán Imperial | 1:4 | ||||
| 2. Jornada | 31.07.2022 | Achuapa | - | CSD Municipal | 1:0 | ||||
| 3. Jornada | 07.08.2022 | CSD Municipal | - | Iztapa | 1:0 | ||||
| 4. Jornada | 11.08.2022 | Antigua GFC | - | CSD Municipal | 0:3 | ||||
| 5. Jornada | 13.08.2022 | CSD Municipal | - | Deportivo Malacateco | 4:1 | ||||
| 6. Jornada | 21.08.2022 | Comunicaciones | - | CSD Municipal | 2:2 | ||||
| 7. Jornada | 28.08.2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 8. Jornada | 01.09.2022 | Deportivo Mixco | - | CSD Municipal | 1:4 | ||||
| 10. Jornada | 11.09.2022 | Santa Lucía | - | CSD Municipal | 1:0 | ||||
| 13. Jornada | 01.10.2022 | CSD Municipal | - | Achuapa | 1:1 | ||||
| 14. Jornada | 09.10.2022 | Iztapa | - | CSD Municipal | 3:2 |  |
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| 12. Jornada | 02.11.2022 | Cobán Imperial | - | CSD Municipal | 0:0 | ||||
| 18. Jornada | 06.11.2022 | Deportivo Guastatoya | - | CSD Municipal | 1:3 | ||||
| 19. Jornada | 12.11.2022 | CSD Municipal | - | Deportivo Mixco | 1:0 |  |
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| 20. Jornada | 17.11.2022 | Xelaju MC | - | CSD Municipal | 1:1 | ||||
| 21. Jornada | 23.11.2022 | CSD Municipal | - | Santa Lucía | 2:0 |
Guatemala