| 3. Jornada | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Jornada | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Jornada | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | ||||
| 6. Jornada | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 |  |
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| 7. Jornada | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 | ||||
| 8. Jornada | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 9. Jornada | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | ||||
| 10. Jornada | 05.08.2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Jornada | 14.08.2021 | Danubio | - | Defensor Sporting | 0:1 | ||||
| 12. Jornada | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 14. Jornada | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | ||||
| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 18. Jornada | 29.10.2021 | Defensor Sporting | - | Villa Teresa | 1:2 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 |  |
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| 22. Jornada | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay