| 1. Jornada | 05.02.2022 | Nacional Potosí | - | Atlético Palmaflor | 1:1 |  |
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| 8. Jornada | 10.04.2022 | Oriente Petrolero | - | Nacional Potosí | 4:2 | |
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| 12. Jornada | 29.04.2022 | CD Guabirá | - | Nacional Potosí | 1:2 | ||||
| 13. Jornada | 07.05.2022 | Real Tomayapo | - | Nacional Potosí | 1:0 | ||||
| 14. Jornada | 12.05.2022 | Nacional Potosí | - | The Strongest | 1:1 | ||||
| 15. Jornada | 15.05.2022 | Club Aurora | - | Nacional Potosí | 2:3 | ||||
| 16. Jornada | 21.05.2022 | Nacional Potosí | - | Oriente Petrolero | 4:2 |
Uruguay