| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 3. Jornada | 17.06.2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 8. Jornada | 21.07.2021 | CA Cerro | - | Uruguay Montevideo | 0:1 |  |
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| 9. Jornada | 31.07.2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 18. Jornada | 29.10.2021 | CA Cerro | - | Juventud de Las Piedras | 2:1 | ||||
| 19. Jornada | 03.11.2021 | Uruguay Montevideo | - | CA Cerro | 1:2 | ||||
| 20. Jornada | 11.11.2021 | CA Cerro | - | Rampla Juniors | 1:2 | |
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| 21. Jornada | 18.11.2021 | Danubio | - | CA Cerro | 0:0 | |
Uruguay