| 3. Jornada | 20.02.2022 | Vélez Sarsfield II | - | Independiente II | 0:0 | ||||
| 4. Jornada | 25.02.2022 | Independiente II | - | Boca Juniors II | 1:1 | ||||
| 5. Jornada | 04.03.2022 | Godoy Cruz II | - | Independiente II | 0:2 | ||||
| 6. Jornada | 14.03.2022 | Independiente II | - | Central Córdoba SdE II | 0:1 | ||||
| 7. Jornada | 22.03.2022 | Independiente II | - | Racing Club II | 2:0 | ||||
| 8. Jornada | 03.04.2022 | Barracas Central II | - | Independiente II | 3:1 | ||||
| 9. Jornada | 07.04.2022 | Independiente II | - | Tigre II | 0:1 | ||||
| 10. Jornada | 13.04.2022 | Colón de Santa Fe II | - | Independiente II | 0:1 | ||||
| 11. Jornada | 19.04.2022 | Independiente II | - | Aldosivi II | 1:2 | ||||
| 12. Jornada | 25.04.2022 | Rosario Central II | - | Independiente II | 1:2 | ||||
| 14. Jornada | 06.05.2022 | Independiente II | - | Huracán II | 0:4 |
Argentina