| 5. Jornada | 27.04.2021 | Audax Italiano | - | Deportes Melipilla | 1:0 | ||||
| 6. Jornada | 03.05.2021 | Deportes Melipilla | - | Universidad Católica | 2:0 | ||||
| 7. Jornada | 09.05.2021 | Santiago Wanderers | - | Deportes Melipilla | 0:3 | ||||
| 8. Jornada | 23.05.2021 | Deportes Melipilla | - | Antofagasta | 1:1 | ||||
| 9. Jornada | 29.05.2021 | La Serena | - | Deportes Melipilla | 5:1 | ||||
| 27. Jornada | 20.10.2021 | O'Higgins | - | Deportes Melipilla | 1:2 | ||||
| 28. Jornada | 24.10.2021 | Deportes Melipilla | - | Universidad de Chile | 3:0 | ||||
| 29. Jornada | 01.11.2021 | Unión La Calera | - | Deportes Melipilla | 2:3 | ||||
| 30. Jornada | 03.11.2021 | Deportes Melipilla | - | Cobresal | 2:1 |  |
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| 33. Jornada | 27.11.2021 | Deportes Melipilla | - | Everton | 1:0 | ||||
| 34. Jornada | 05.12.2021 | Huachipato | - | Deportes Melipilla | 3:1 | |
Chile