| 4. Jornada | 15.08.2021 | Spartak Trnava | - | Zlaté Moravce | 2:0 | ||||
| 5. Jornada | 21.08.2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 6. Jornada | 29.08.2021 | Spartak Trnava | - | MŠK Žilina | 1:1 |  |
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| 16. Jornada | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Jornada | 05.12.2021 | MŠK Žilina | - | Spartak Trnava | 0:1 | ||||
| 18. Jornada | 10.12.2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
| 19. Jornada | 18.12.2021 | ŠKF Sereď | - | Spartak Trnava | 0:1 | |
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| 20. Jornada | 13.02.2022 | Spartak Trnava | - | FC DAC 1904 | 1:1 | ||||
| 21. Jornada | 19.02.2022 | Spartak Trnava | - | AS Trenčín | 0:0 | ||||
| 22. Jornada | 26.02.2022 | Slovan Bratislava | - | Spartak Trnava | 0:0 |
Eslovaquia