| 3. Jornada | 22.01.2022 | UANL Tigres [] | - | Santos Laguna [] | 2:1 | ||||
| 4. Jornada | 29.01.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:0 | ||||
| 5. Jornada | 04.02.2022 | Atlético San Luis [] | - | Santos Laguna [] | 0:2 | ||||
| 8. Jornada | 26.02.2022 | Mazatlán FC [] | - | Santos Laguna [] | 0:3 | ||||
| 15. Jornada | 20.04.2022 | Club Tijuana [] | - | Santos Laguna [] | 4:1 | ||||
| 16. Jornada | 23.04.2022 | Santos Laguna [] | - | UANL Tigres [] | 5:0 | ||||
| 17. Jornada | 30.04.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 4:0 |
México