| 9. Jornada | 25.09.2021 | FK Pardubice | - | Viktoria Plzeň | 0:1 | ||||
| 10. Jornada | 02.10.2021 | Dynamo České Budějovice | - | FK Pardubice | 3:1 |  |
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| 11. Jornada | 17.10.2021 | FK Pardubice | - | Sparta Praga | 2:4 |  |
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| 12. Jornada | 23.10.2021 | FK Pardubice | - | FC Fastav Zlín | 0:0 | ||||
| 13. Jornada | 31.10.2021 | FK Jablonec | - | FK Pardubice | 1:1 | ||||
| 14. Jornada | 07.11.2021 | FK Pardubice | - | Slavia Praga | 0:5 |
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