| 1. Jornada | 16.01.2022 | Luis Ángel Firpo | - | Municipal Limeño | 1:0 | ||||
| 2. Jornada | 23.01.2022 | Municipal Limeño | - | Platense Zacatecoluca | 2:1 |  |
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| 3. Jornada | 26.01.2022 | Once Municipal | - | Municipal Limeño | 3:2 | ||||
| 4. Jornada | 30.01.2022 | Municipal Limeño | - | CD Águila | 0:3 | ||||
| 5. Jornada | 04.02.2022 | Jocoro FC | - | Municipal Limeño | 3:0 | ||||
| 6. Jornada | 09.02.2022 | Municipal Limeño | - | FAS | 1:1 | ||||
| 7. Jornada | 13.02.2022 | Santa Tecla FC | - | Municipal Limeño | 1:1 | |
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| 8. Jornada | 20.02.2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Jornada | 23.02.2022 | Municipal Limeño | - | Atlético Marte | 2:0 | ||||
| 11. Jornada | 06.03.2022 | Municipal Limeño | - | AD Chalatenango | 0:1 | ||||
| 14. Jornada | 25.03.2022 | Municipal Limeño | - | Once Municipal | 0:0 | ||||
| 15. Jornada | 03.04.2022 | CD Águila | - | Municipal Limeño | 1:0 | |
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| 16. Jornada | 10.04.2022 | Municipal Limeño | - | Jocoro FC | 2:2 | ||||
| 19. Jornada | 24.04.2022 | Alianza | - | Municipal Limeño | 4:0 | ||||
| 20. Jornada | 27.04.2022 | Atlético Marte | - | Municipal Limeño | 0:1 | ||||
| 21. Jornada | 01.05.2022 | Municipal Limeño | - | Isidro Metapán | 1:0 |
El Salvador