| 1. Jornada | 25.07.2021 | Viktoria Plzeň | - | FK Mladá Boleslav | 2:1 | ||||
| 2. Jornada | 01.08.2021 | Bohemians Praha 1905 | - | Viktoria Plzeň | 1:2 | ||||
| 4. Jornada | 15.08.2021 | Slovan Liberec | - | Viktoria Plzeň | 0:1 |  |
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| 5. Jornada | 22.08.2021 | Viktoria Plzeň | - | MFK Karviná | 2:0 | ||||
| 6. Jornada | 29.08.2021 | FC Hradec Králové | - | Viktoria Plzeň | 1:0 | ||||
| 7. Jornada | 11.09.2021 | Viktoria Plzeň | - | Sparta Praga | 3:2 | |
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| 11. Jornada | 17.10.2021 | FK Teplice | - | Viktoria Plzeň | 0:1 | ||||
| 12. Jornada | 24.10.2021 | Viktoria Plzeň | - | FK Jablonec | 5:0 |
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