| 2. Jornada | 23.07.2021 | Rosario Central II | - | Vélez Sarsfield II | 3:0 | ||||
| 3. Jornada | 27.07.2021 | Gimnasia de La Plata II | - | Rosario Central II | 4:3 | ||||
| 7. Jornada | 20.08.2021 | Newell's Old Boys II | - | Rosario Central II | 1:1 | ||||
| 8. Jornada | 24.08.2021 | Rosario Central II | - | Arsenal de Sarandí II | 4:0 |  |
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| 9. Jornada | 30.08.2021 | Central Córdoba SdE II | - | Rosario Central II | 0:1 | ||||
| 10. Jornada | 03.09.2021 | Rosario Central II | - | Boca Juniors II | 1:3 | ||||
| 11. Jornada | 14.09.2021 | Banfield II | - | Rosario Central II | 1:3 | ||||
| 12. Jornada | 17.09.2021 | Rosario Central II | - | San Lorenzo II | 1:2 | ||||
| 13. Jornada | 24.09.2021 | Talleres de Córdoba II | - | Rosario Central II | 3:1 | ||||
| 14. Jornada | 01.10.2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 15. Jornada | 08.10.2021 | Estudiantes II | - | Rosario Central II | 1:1 | ||||
| 16. Jornada | 13.10.2021 | Rosario Central II | - | Patronato de Paraná II | 2:1 | ||||
| 17. Jornada | 18.10.2021 | Platense II | - | Rosario Central II | 0:3 | |
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| 18. Jornada | 24.10.2021 | Rosario Central II | - | Racing Club II | 1:2 | ||||
| 19. Jornada | 29.10.2021 | Unión de Santa Fe II | - | Rosario Central II | 0:0 |
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