| 1. Jornada | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 |  |
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| 2. Jornada | 11.06.2021 | CA Cerro | - | Defensor Sporting | 0:0 | |
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| 3. Jornada | 16.06.2021 | Albion | - | Defensor Sporting | 2:2 | ||||
| 4. Jornada | 26.06.2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Jornada | 01.07.2021 | Atenas | - | Defensor Sporting | 2:0 | |
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| 13. Jornada | 23.09.2021 | Defensor Sporting | - | CA Cerro | 2:0 |  |
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| 14. Jornada | 30.09.2021 | Defensor Sporting | - | Albion | 0:1 | |
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| 16. Jornada | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | |
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| 17. Jornada | 20.10.2021 | Racing | - | Defensor Sporting | 0:1 | ||||
| 19. Jornada | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 |
Uruguay