| 1. Jornada | 17.05.2021 | Cerrito | - | River Plate | 3:1 | ||||
| 2. Jornada | 24.05.2021 | River Plate | - | Liverpool | 3:2 |  |
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| 3. Jornada | 30.05.2021 | Deportivo Maldonado | - | River Plate | 0:0 | ||||
| 4. Jornada | 06.06.2021 | Cerro Largo | - | River Plate | 2:4 |  |
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| 5. Jornada | 12.06.2021 | River Plate | - | Progreso | 4:0 | ||||
| 6. Jornada | 19.06.2021 | Sud América | - | River Plate | 1:2 | |
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| 7. Jornada | 22.06.2021 | River Plate | - | Plaza Colonia | 0:1 | ||||
| 8. Jornada | 26.06.2021 | Fénix | - | River Plate | 3:4 | |
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| 9. Jornada | 03.07.2021 | River Plate | - | Boston River | 1:1 | |
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| 10. Jornada | 10.07.2021 | Montevideo Wanderers | - | River Plate | 1:2 | |
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| 11. Jornada | 17.07.2021 | River Plate | - | Rentistas | 0:0 | ||||
| 12. Jornada | 01.08.2021 | Peñarol | - | River Plate | 2:0 | ||||
| 13. Jornada | 07.08.2021 | River Plate | - | Montevideo City Torque | 3:3 | |
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| 14. Jornada | 15.08.2021 | Villa Española | - | River Plate | 1:1 | |
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| 15. Jornada | 21.08.2021 | River Plate | - | Nacional | 2:0 | |
Uruguay