| 1. Jornada | 11.09.2021 | River Plate | - | Cerrito | 1:0 |  |
|||
| 2. Jornada | 19.09.2021 | Liverpool | - | River Plate | 3:1 | ||||
| 3. Jornada | 25.09.2021 | River Plate | - | Deportivo Maldonado | 1:2 | |
 |
||
| 4. Jornada | 02.10.2021 | River Plate | - | Cerro Largo | 0:4 | ||||
| 5. Jornada | 09.10.2021 | Progreso | - | River Plate | 1:0 | |
|||
| 7. Jornada | 20.10.2021 | Plaza Colonia | - | River Plate | 0:0 | |
|||
| 8. Jornada | 25.10.2021 | River Plate | - | Fénix | 0:0 | ||||
| 9. Jornada | 30.10.2021 | Boston River | - | River Plate | 1:2 | |
|||
| 10. Jornada | 03.11.2021 | River Plate | - | Montevideo Wanderers | 0:1 | ||||
| 11. Jornada | 06.11.2021 | Rentistas | - | River Plate | 1:0 | |
|||
| 12. Jornada | 14.11.2021 | River Plate | - | Peñarol | 1:1 | ||||
| 13. Jornada | 22.11.2021 | Montevideo City Torque | - | River Plate | 1:1 | |
|||
| 14. Jornada | 30.11.2021 | River Plate | - | Villa Española | 4:2 | |
|||
| 15. Jornada | 04.12.2021 | Nacional | - | River Plate | 4:2 |
Uruguay