| 1. Jornada | 24.07.2021 | CF Pachuca | - | Club León | 4:0 |  |
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| 2. Jornada | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Jornada | 10.08.2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 |  |
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| 6. Jornada | 23.08.2021 | Gallos Blancos | - | CF Pachuca | 0:2 | ||||
| 8. Jornada | 14.09.2021 | CF Pachuca | - | Deportivo Toluca | 1:2 | ||||
| 9. Jornada | 19.09.2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
| 10. Jornada | 24.09.2021 | CF Pachuca | - | Club Necaxa | 1:0 | ||||
| 11. Jornada | 29.09.2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 12. Jornada | 02.10.2021 | Puebla FC | - | CF Pachuca | 1:2 |  |
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| 14. Jornada | 21.10.2021 | UANL Tigres | - | CF Pachuca | 3:0 | ||||
| 17. Jornada | 07.11.2021 | Club Tijuana | - | CF Pachuca | 3:2 |
Argentina
Chile