| 1. Jornada | 30.04.2022 | Miramar Misiones | - | Progreso | 0:1 |  |
|||
| 2. Jornada | 07.05.2022 | Progreso | - | Villa Española | 2:0 | |
 |
||
| 3. Jornada | 16.05.2022 | Juventud de Las Piedras | - | Progreso | 0:0 | |
|||
| 4. Jornada | 22.05.2022 | Progreso | - | Racing | 0:2 | ||||
| 5. Jornada | 25.05.2022 | Rampla Juniors | - | Progreso | 1:1 | |
|||
| 6. Jornada | 28.05.2022 | Progreso | - | Uruguay Montevideo | 0:2 | ||||
| 11. Jornada | 25.06.2022 | Progreso | - | Central Español | 1:1 | ||||
| 12. Jornada | 23.07.2022 | Progreso | - | Miramar Misiones | 1:1 | |
|||
| 13. Jornada | 30.07.2022 | Villa Española | - | Progreso | 0:0 | ||||
| 14. Jornada | 06.08.2022 | Progreso | - | Juventud de Las Piedras | 0:1 | ||||
| 15. Jornada | 14.08.2022 | Racing | - | Progreso | 2:1 | ||||
| 16. Jornada | 20.08.2022 | Progreso | - | Rampla Juniors | 0:1 | |
|||
| 17. Jornada | 24.08.2022 | Uruguay Montevideo | - | Progreso | 1:0 | ||||
| 18. Jornada | 28.08.2022 | La Luz | - | Progreso | 1:1 | ||||
| 19. Jornada | 03.09.2022 | Progreso | - | Atenas | 1:0 | ||||
| 21. Jornada | 17.09.2022 | Progreso | - | Sud América | 3:1 | ||||
| 22. Jornada | 25.09.2022 | Central Español | - | Progreso | 1:1 | |
Uruguay