| 1. Jornada | 07.02.2022 | River Plate | - | Montevideo Wanderers | 1:1 |  |
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| 2. Jornada | 12.02.2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
| 3. Jornada | 19.02.2022 | River Plate | - | Boston River | 1:2 | ||||
| 4. Jornada | 28.02.2022 | River Plate | - | Cerrito | 3:1 |  |
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| 5. Jornada | 05.03.2022 | River Plate | - | Cerro Largo | 1:1 | ||||
| 7. Jornada | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
| 8. Jornada | 10.04.2022 | River Plate | - | Albion | 4:1 | |
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| 10. Jornada | 23.04.2022 | River Plate | - | Danubio | 0:0 | ||||
| 11. Jornada | 07.05.2022 | Deportivo Maldonado | - | River Plate | 2:1 | |
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| 12. Jornada | 13.05.2022 | River Plate | - | Rentistas | 1:0 | ||||
| 13. Jornada | 22.05.2022 | Liverpool | - | River Plate | 2:1 | ||||
| 14. Jornada | 29.05.2022 | River Plate | - | Peñarol | 0:0 | ||||
| 15. Jornada | 04.06.2022 | Montevideo City Torque | - | River Plate | 0:0 |
Uruguay