| 1. Jornada | 17.02.2022 | Cobreloa | - | San Luis | 2:1 | ||||
| 2. Jornada | 23.02.2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Jornada | 17.03.2022 | San Luis | - | Santiago Morning | 1:2 | ||||
| 6. Jornada | 23.03.2022 | Rangers | - | San Luis | 2:3 | ||||
| 7. Jornada | 03.04.2022 | San Luis | - | Deportes Copiapó | 0:0 | ||||
| 8. Jornada | 12.04.2022 | Unión San Felipe | - | San Luis | 2:0 | ||||
| 13. Jornada | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 15. Jornada | 18.05.2022 | Santa Cruz | - | San Luis | 2:0 |
Uruguay