| 7. Jornada | 11.09.2021 | FK Teplice | - | Baník Ostrava | 1:2 |  |
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| 8. Jornada | 19.09.2021 | MFK Karviná | - | FK Teplice | 1:1 | ||||
| 9. Jornada | 26.09.2021 | FK Teplice | - | Sigma Olomouc | 0:0 | ||||
| 10. Jornada | 02.10.2021 | 1. FC Slovácko | - | FK Teplice | 3:2 | ||||
| 11. Jornada | 17.10.2021 | FK Teplice | - | Viktoria Plzeň | 0:1 | ||||
| 12. Jornada | 24.10.2021 | FC Hradec Králové | - | FK Teplice | 3:0 | ||||
| 13. Jornada | 30.10.2021 | FK Teplice | - | Slovan Liberec | 1:2 | |
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| 14. Jornada | 07.11.2021 | Sparta Praga | - | FK Teplice | 4:2 |  |
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| 15. Jornada | 21.11.2021 | FK Teplice | - | FK Pardubice | 1:2 | ||||
| 19. Jornada | 19.12.2021 | FK Teplice | - | FK Mladá Boleslav | 0:1 | ||||
| 29. Jornada | 17.04.2022 | FK Pardubice | - | FK Teplice | 2:0 |
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