| 1. Jornada | 15.08.2021 | Tottenham Hotspur | - | Manchester City | 1:0 | ||||
| 11. Jornada | 07.11.2021 | Everton | - | Tottenham Hotspur | 0:0 | ||||
| 15. Jornada | 05.12.2021 | Tottenham Hotspur | - | Norwich City | 3:0 | ||||
| 20. Jornada | 28.12.2021 | Southampton | - | Tottenham Hotspur | 1:1 | ||||
| 17. Jornada | 19.01.2022 | Leicester City | - | Tottenham Hotspur | 2:3 | ||||
| 23. Jornada | 23.01.2022 | Chelsea | - | Tottenham Hotspur | 2:0 | ||||
| 25. Jornada | 13.02.2022 | Tottenham Hotspur | - | Wolverhampton Wanderers | 0:2 | ||||
| 26. Jornada | 19.02.2022 | Manchester City | - | Tottenham Hotspur | 2:3 | ||||
| 27. Jornada | 26.02.2022 | Leeds United | - | Tottenham Hotspur | 0:4 |  |
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| 28. Jornada | 07.03.2022 | Tottenham Hotspur | - | Everton | 5:0 | ||||
| 29. Jornada | 12.03.2022 | Manchester United | - | Tottenham Hotspur | 3:2 | ||||
| 16. Jornada | 16.03.2022 | Brighton & Hove Albion | - | Tottenham Hotspur | 0:2 | ||||
| 30. Jornada | 20.03.2022 | Tottenham Hotspur | - | West Ham United | 3:1 | ||||
| 31. Jornada | 03.04.2022 | Tottenham Hotspur | - | Newcastle United | 5:1 | |
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| 32. Jornada | 09.04.2022 | Aston Villa | - | Tottenham Hotspur | 0:4 |
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