| 17. Jornada | 05.02.2022 | Gżira United | - | Hamrun Spartans | 4:1 | ||||
| 18. Jornada | 13.02.2022 | Hamrun Spartans | - | Gudja United | 0:1 | ||||
| 19. Jornada | 19.02.2022 | Sirens FC | - | Hamrun Spartans | 1:1 |  |
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| 20. Jornada | 26.02.2022 | Hamrun Spartans | - | Hibernians FC | 0:0 |  |
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| 21. Jornada | 06.03.2022 | St. Luċija FC | - | Hamrun Spartans | 0:1 | ||||
| 22. Jornada | 11.03.2022 | Hamrun Spartans | - | Sliema Wanderers | 3:1 |
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