| 6. Jornada | 16.10.2021 | Hamrun Spartans | - | Gżira United | 0:1 | ||||
| 7. Jornada | 23.10.2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
| 8. Jornada | 30.10.2021 | Hamrun Spartans | - | Sirens FC | 1:0 | ||||
| 9. Jornada | 21.11.2021 | Hibernians FC | - | Hamrun Spartans | 1:0 | ||||
| 10. Jornada | 28.11.2021 | Hamrun Spartans | - | St. Luċija FC | 3:0 | ||||
| 11. Jornada | 05.12.2021 | Sliema Wanderers | - | Hamrun Spartans | 0:2 |  |
 |
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| 12. Jornada | 13.12.2021 | Valletta FC | - | Hamrun Spartans | 0:1 | ||||
| 14. Jornada | 17.01.2022 | Hamrun Spartans | - | Mosta FC | 2:1 | ||||
| 15. Jornada | 22.01.2022 | Balzan FC | - | Hamrun Spartans | 2:2 | ||||
| 13. Jornada | 26.01.2022 | Hamrun Spartans | - | Birkirkara FC | 0:0 | |
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| 16. Jornada | 30.01.2022 | Hamrun Spartans | - | Floriana FC | 2:2 |
Malta
Inglaterra