| 1. Jornada | 04.02.2022 | Universitario de Vinto | - | Real Tomayapo | 1:1 |  |
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| 2. Jornada | 13.02.2022 | Real Tomayapo | - | Independiente Petrolero | 1:1 |  |
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| 3. Jornada | 19.02.2022 | Always Ready | - | Real Tomayapo | 0:1 | |
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| 4. Jornada | 26.02.2022 | Real Tomayapo | - | Royal Pari | 1:0 | |
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| 13. Jornada | 07.05.2022 | Real Tomayapo | - | Nacional Potosí | 1:0 | ||||
| 14. Jornada | 13.05.2022 | Bolívar | - | Real Tomayapo | 1:0 | ||||
| 15. Jornada | 15.05.2022 | Real Tomayapo | - | Jorge Wilstermann | 1:1 | ||||
| 16. Jornada | 22.05.2022 | Blooming | - | Real Tomayapo | 2:1 |
Bolivia