| 4. Jornada | 08.08.2016 | Puebla FC | - | Santos Laguna | 0:0 | ||||
| 5. Jornada | 15.08.2016 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 6. Jornada | 21.08.2016 | Cruz Azul | - | Santos Laguna | 3:1 | ||||
| 7. Jornada | 29.08.2016 | Santos Laguna | - | Club León | 1:0 | ||||
| 8. Jornada | 11.09.2016 | Club Necaxa | - | Santos Laguna | 2:1 |  |
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| 9. Jornada | 19.09.2016 | Santos Laguna | - | Pumas UNAM | 3:1 | |
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| 10. Jornada | 22.09.2016 | CF Monterrey | - | Santos Laguna | 5:2 |  |
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| 11. Jornada | 26.09.2016 | Santos Laguna | - | Club Tijuana | 1:2 | ||||
| 12. Jornada | 02.10.2016 | Gallos Blancos | - | Santos Laguna | 1:1 | ||||
| 13. Jornada | 16.10.2016 | CF Pachuca | - | Santos Laguna | 3:0 | ||||
| 15. Jornada | 30.10.2016 | CF América | - | Santos Laguna | 3:1 |
Colombia
