| 1. Jornada | 21.07.2018 | Boston River | - | River Plate | 2:3 |  |
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| 2. Jornada | 29.07.2018 | River Plate | - | Peñarol | 0:1 | ||||
| 3. Jornada | 04.08.2018 | Atenas | - | River Plate | 1:1 | |
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| 4. Jornada | 12.08.2018 | River Plate | - | Danubio | 1:2 | ||||
| 8. Jornada | 09.09.2018 | River Plate | - | Nacional | 0:0 | ||||
| 9. Jornada | 16.09.2018 | Progreso | - | River Plate | 2:2 | ||||
| 10. Jornada | 23.09.2018 | River Plate | - | Defensor Sporting | 3:2 | |
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| 11. Jornada | 07.10.2018 | Racing | - | River Plate | 2:1 | |
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| 12. Jornada | 14.10.2018 | CA Cerro | - | River Plate | 4:2 | ||||
| 13. Jornada | 21.10.2018 | River Plate | - | Montevideo Wanderers | 0:5 |  |
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| 14. Jornada | 28.10.2018 | Liverpool | - | River Plate | 4:1 |
Uruguay