| 2. Jornada | 17.01.2021 | Cruz Azul | - | Puebla FC | 0:1 |  |
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| 3. Jornada | 23.01.2021 | Puebla FC | - | Club Tijuana | 0:1 | ||||
| 4. Jornada | 03.02.2021 | Puebla FC | - | CF Monterrey | 0:0 | ||||
| 5. Jornada | 07.02.2021 | CF América | - | Puebla FC | 1:0 |  |
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| 7. Jornada | 22.02.2021 | Gallos Blancos | - | Puebla FC | 1:1 | |
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| 9. Jornada | 03.03.2021 | Club León | - | Puebla FC | 1:2 | ||||
| 10. Jornada | 06.03.2021 | Puebla FC | - | UANL Tigres | 1:1 | ||||
| 11. Jornada | 13.03.2021 | Puebla FC | - | Atlas Guadalajara | 0:1 | ||||
| 12. Jornada | 21.03.2021 | Deportivo Toluca | - | Puebla FC | 4:4 | ||||
| 13. Jornada | 03.04.2021 | Puebla FC | - | Mazatlán FC | 3:1 | ||||
| 14. Jornada | 13.04.2021 | CF Pachuca | - | Puebla FC | 1:3 |  |
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| 15. Jornada | 18.04.2021 | Atlético San Luis | - | Puebla FC | 1:4 | ||||
| 16. Jornada | 24.04.2021 | Puebla FC | - | Pumas UNAM | 0:0 | ||||
| 17. Jornada | 03.05.2021 | Santos Laguna | - | Puebla FC | 0:0 | |
Uruguay