| 12. Jornada | 06.06.2021 | Guayaquil SC | - | Gualaceo SC | 1:1 | ||||
| 13. Jornada | 11.06.2021 | El Nacional | - | Guayaquil SC | 2:0 |  |
|||
| 14. Jornada | 13.06.2021 | Guayaquil SC | - | Atlético Porteño | 1:0 | ||||
| 15. Jornada | 16.06.2021 | Atlético Santo Domingo | - | Guayaquil SC | 0:1 | |
|||
| 16. Jornada | 20.06.2021 | Guayaquil SC | - | América de Quito | 0:2 | ||||
| 17. Jornada | 23.06.2021 | Chacaritas FC | - | Guayaquil SC | 2:3 | ||||
| 18. Jornada | 27.06.2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 | ||||
| 19. Jornada | 04.07.2021 | Atlético Porteño | - | Guayaquil SC | 4:1 | ||||
| 20. Jornada | 08.07.2021 | Guayaquil SC | - | El Nacional | 3:1 | ||||
| 21. Jornada | 11.07.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | |
|||
| 22. Jornada | 16.07.2021 | Independiente Juniors | - | Guayaquil SC | 1:2 | |
|||
| 23. Jornada | 18.07.2021 | Guayaquil SC | - | Cumbayá | 1:2 |  |
|||
| 24. Jornada | 22.07.2021 | Liga de Portoviejo | - | Guayaquil SC | 2:0 | ||||
| 25. Jornada | 29.07.2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | |
|||
| 27. Jornada | 12.08.2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 | ||||
| 29. Jornada | 26.08.2021 | Guayaquil SC | - | Gualaceo SC | 0:2 | |
|||
| 31. Jornada | 09.09.2021 | Cumbayá | - | Guayaquil SC | 1:0 |  |
Ecuador