| 1. Jornada | 17.08.2018 | FC Twente | - | Sparta Rotterdam | 2:1 | ||||
| 2. Jornada | 24.08.2018 | Helmond Sport | - | FC Twente | 2:2 | ||||
| 3. Jornada | 31.08.2018 | FC Twente | - | Roda JC Kerkrade | 3:1 | ||||
| 4. Jornada | 08.09.2018 | FC Twente | - | TOP Oss | 1:2 | ||||
| 10. Jornada | 22.10.2018 | FC Utrecht (J) | - | FC Twente | 1:6 | ||||
| 12. Jornada | 02.11.2018 | FC Twente | - | RKC Waalwijk | 3:1 |  |
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| 13. Jornada | 09.11.2018 | FC Den Bosch | - | FC Twente | 2:1 | ||||
| 15. Jornada | 26.11.2018 | AZ Alkmaar (J) | - | FC Twente | 1:2 | ||||
| 16. Jornada | 30.11.2018 | FC Twente | - | Jong Ajax | 2:5 | ||||
| 25. Jornada | 18.02.2019 | Jong PSV | - | FC Twente | 0:2 |
Países Bajos