| 1. Jornada | 25.07.2021 | Slovan Liberec | - | 1. FC Slovácko | 0:1 | ||||
| 2. Jornada | 31.07.2021 | Slovan Liberec | - | Sparta Praga | 0:5 | ||||
| 3. Jornada | 07.08.2021 | FC Hradec Králové | - | Slovan Liberec | 1:1 | ||||
| 4. Jornada | 15.08.2021 | Slovan Liberec | - | Viktoria Plzeň | 0:1 | ||||
| 5. Jornada | 22.08.2021 | Dynamo České Budějovice | - | Slovan Liberec | 1:0 |  |
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| 6. Jornada | 28.08.2021 | Slovan Liberec | - | FC Fastav Zlín | 0:1 | ||||
| 7. Jornada | 11.09.2021 | FK Pardubice | - | Slovan Liberec | 2:2 | |
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| 8. Jornada | 18.09.2021 | Slovan Liberec | - | FK Mladá Boleslav | 2:1 | ||||
| 9. Jornada | 26.09.2021 | FK Jablonec | - | Slovan Liberec | 0:1 | ||||
| 10. Jornada | 03.10.2021 | Slovan Liberec | - | Baník Ostrava | 0:2 | ||||
| 11. Jornada | 16.10.2021 | Slavia Praga | - | Slovan Liberec | 3:1 | ||||
| 13. Jornada | 30.10.2021 | FK Teplice | - | Slovan Liberec | 1:2 | ||||
| 14. Jornada | 06.11.2021 | Slovan Liberec | - | Bohemians Praha 1905 | 2:1 | ||||
| 15. Jornada | 21.11.2021 | MFK Karviná | - | Slovan Liberec | 1:2 | ||||
| 16. Jornada | 28.11.2021 | Sparta Praga | - | Slovan Liberec | 2:1 | ||||
| 27. Jornada | 02.04.2022 | Slovan Liberec | - | FK Teplice | 0:1 |
Eslovaquia