| 1. Jornada | 31.07.2022 | Slavia Praha B | - | 1. SK Prostějov | 0:1 | ||||
| 2. Jornada | 06.08.2022 | 1. SK Prostějov | - | FK Třinec | 1:1 | ||||
| 3. Jornada | 14.08.2022 | FK Varnsdorf | - | 1. SK Prostějov | 2:0 | ||||
| 4. Jornada | 20.08.2022 | 1. SK Prostějov | - | Sigma Olomouc B | 1:3 | ||||
| 6. Jornada | 31.08.2022 | 1. SK Prostějov | - | MFK Chrudim | 1:1 |  |
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| 7. Jornada | 04.09.2022 | FC Sellier & Bellot Vlašim | - | 1. SK Prostějov | 6:1 | ||||
| 5. Jornada | 07.09.2022 | FK Viagem Příbram | - | 1. SK Prostějov | 2:2 |  |
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| 9. Jornada | 17.09.2022 | MFK Vyškov | - | 1. SK Prostějov | 4:1 | ||||
| 10. Jornada | 01.10.2022 | 1. SK Prostějov | - | AC Sparta Praha B | 0:2 | ||||
| 12. Jornada | 15.10.2022 | 1. SK Prostějov | - | MFK Karviná | 2:1 | |
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| 14. Jornada | 29.10.2022 | 1. SK Prostějov | - | SFC Opava | 2:2 | ||||
| 15. Jornada | 05.11.2022 | 1. SK Prostějov | - | FK Dukla Praha | 4:2 |
República Checa