| 1. Jornada | 18.09.2021 | FC Juárez [] | - | Puebla FC [] | 1:0 | ||||
| 2. Jornada | 25.09.2021 | Puebla FC [] | - | Deportivo Toluca [] | 2:1 | ||||
| 3. Jornada | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
| 4. Jornada | 09.10.2021 | Club Tijuana [] | - | Puebla FC [] | 5:0 | ||||
| 5. Jornada | 16.10.2021 | Puebla FC [] | - | Gallos Blancos [] | 0:1 | ||||
| 7. Jornada | 30.10.2021 | Puebla FC [] | - | FC Juárez [] | 2:1 |  |
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| 8. Jornada | 06.11.2021 | Cruz Azul [] | - | Puebla FC [] | 2:2 |  |
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| 10. Jornada | 20.11.2021 | Puebla FC [] | - | Pumas UNAM [] | 2:4 |
México