| 1. Jornada | 08.01.2022 | CF Pachuca [] | - | Puebla FC [] | 2:0 | ||||
| 2. Jornada | 15.01.2022 | Puebla FC [] | - | Gallos Blancos [] | 0:0 | ||||
| 5. Jornada | 05.02.2022 | Club Necaxa [] | - | Puebla FC [] | 4:0 | ||||
| 8. Jornada | 26.02.2022 | Cruz Azul [] | - | Puebla FC [] | 4:1 | ||||
| 9. Jornada | 05.03.2022 | Puebla FC [] | - | FC Juárez [] | 3:2 | ||||
| 10. Jornada | 12.03.2022 | Deportivo Toluca [] | - | Puebla FC [] | 2:1 | ||||
| 12. Jornada | 26.03.2022 | Puebla FC [] | - | Club Necaxa [] | 0:3 | ||||
| 13. Jornada | 02.04.2022 | Gallos Blancos [] | - | Puebla FC [] | 0:3 | ||||
| 16. Jornada | 23.04.2022 | Puebla FC [] | - | Cruz Azul [] | 0:2 | ||||
| 18. Jornada | 07.05.2022 | Pumas UNAM [] | - | Puebla FC [] | 2:1 |
México